Removing a specific value - but only for a specific fileformat

Either you use $upper with the extension comparison in UPPERCASE

$if($eql('TTA',$upper(%_EXTENSION%)),$repl(%TITLE%,' TTA',' '),)

or you use $lower with the extension comparison in lowercase

$if($eql('tta',$lower(%_EXTENSION%)),$repl(%TITLE%,' TTA',' '),)

Do you want to replace the tta string in all variations like tta, tTa, tTA, TTa, ttA, TTA?
Or what case should be ignored?

Later added warning:

Please don't use this abbreviated syntax!

As found in this bug report, the abbrevation of $repl instead of using $replace can result in unwanted changes. Always use $replace as stated in the help.