I have already tried saving the files after adding only the comment, It saved the comment but cleared all the other tags.
I tried your way with ctr + s It cleared all tags, even the comment.
Tried another Three times, It saves the Comment but clears the other Tags.
Then you have to describe how you do it.
Because, by default, MP3tag sets all fields in the tag panel to "keep" if you select more than one file.
Nothing gets cleared unless you tamper with these settings.
What you could also check: what kind of tag versions have you got in the files, Like APE, ID3V1, ID3V2?