It would be nice to have the option in the preferences to set all files' attributes to "read-only" when closing Mp3Tag.
It's a neat little trick I got in the habit of doing after I tag an album to my liking. It prevents all applications from modifying the tags (eg. WMP and iTunes).
Mp3Tag already handles read-only files by asking you if you want to disable protection when modifying tags, so such an option wouldn't make things more complicated.