Is it possible to get rid of all comments for a large set of files all at once?

I'm hoping there is some quick way to just change the comments of 2k+ mp3s to be blank. All help is appreciated.

Yep, easy to do. Simply load all files into mp3tag, select them all, select "extended tags", in the metadata table to the left highlight the "comment" column, then click on the red X to delete that field. This will "blank" all the comment fields in the files you've selected.